目的 :制备醋酸地塞米松凝胶剂 ,考察其质量与体外释放的特征。方法 :以醋酸地塞米松为主药 ,卡波谱为凝胶基质 ,制备醋酸地塞米松眼用凝胶剂 ,用紫外分光光度法测定其含量 ,用透析法考察其体外释放行为。结果 :醋酸地塞米松凝胶剂中醋酸地塞米松的平均含量为标示量的 99.5 1% ,RSD 1.4 3%。透析实验考察一周 ,平均释药百分率为 6 8.2 6 %。结论 :该凝胶剂制备简单 ,性质稳定 ,质量可控 ,释放时间延长 Objective: To prepare dexamethasone acetate gel and investigate its quality and in vitro release characteristics. Methods: Dexamethasone acetate was used as the main drug. The Karbels spectrum was gel matrix. Acetate dexamethasone eye gel was prepared. The content of dexamethasone acetate gel was determined by UV spectrophotometry. The in vitro release behavior was investigated by dialysis. Results: The average content of dexamethasone acetate in dexamethasone acetate gel was 99.5 1% of labeled amount and 1.4 3% of RSD. A week of dialysis experiments, the average percentage release was 6 8.2 6%. Conclusion: The gel preparation is simple, stable in nature, controllable in quality and prolonged in release time