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血清泌乳素(PRL)的测定对于鉴别泌乳素瘤和无功能腺瘤是重要的。免疫放射测定法常用作PRL的测定,用短期孵育是一种敏感的和精确的方法。然而,在有大量抗原存在时用这一技术可能错误地报告为低值。这种现象称为高剂量欺骗结果(high dosehook effect)。为了确定高剂量PRL欺骗结果的患病率及其提示这一诊断的临床特征,作者对此作了有关的研究。 在1989至1994年期间用免疫放射测定法测定了54例垂体无功能性腺瘤,11例经蝶显微外科的巨大泌乳素瘤和4例高剂量PRL欺骗结果的共69个病人。
The determination of serum prolactin (PRL) is important for the identification of prolactinomas and nonfunctioning adenomas. Immunoradiometric assays are often used as a measure of PRL, and a short-term incubation is a sensitive and accurate method. However, using this technique in the presence of a large number of antigens may falsely report a low value. This phenomenon is called a high dose hook effect. In order to determine the prevalence of high-dose PRL spoofing results and to suggest the clinical features of this diagnosis, the authors conducted a related study. Between 1989 and 1994, 54 cases of pituitary nonfunctioning adenomas, 11 cases of giant prolactinomas treated with butterfly microsurgery, and 69 cases of high-dose PRL deception results were measured by immunoradiometric assay.