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目的了解catenin在妊娠期糖尿病患者中的表达及作用。方法收集正常妊娠组50例,妊娠期糖尿病组50例(饮食控制者30例,使用胰岛素者20例)的空腹血及胎盘组织,采用酶联免疫吸附法检测空腹血中catenin的表达情况;采用免疫组化法检测胎盘组织中catenin的表达情况。结果 catenin在妊娠期糖尿病患者中表达明显高于正常妊娠组;应用胰岛素控制血糖者catenin表达明显高于饮食控制者,差异均有显著性(P<0.05)。结论 catenin表达异常可能是妊娠期糖尿病发生的早期事件,为疾病的预测及防治提供新的思路。
Objective To investigate the expression and role of catenin in gestational diabetes mellitus. Methods Fasting blood and placental tissue were collected from 50 normal pregnant women and 50 pregnant women with gestational diabetes mellitus (30 diet-control subjects and 20 insulin-treated subjects). The expression of catenin in fasting blood was detected by enzyme-linked immunosorbent assay The expression of catenin in placenta was detected by immunohistochemistry. Results The expression of catenin in gestational diabetes mellitus patients was significantly higher than that in normal pregnancy group. The catenin expression was significantly higher in patients with gestational diabetes mellitus than those in diet controls (P <0.05). Conclusion Abnormal expression of catenin may be an early event in the development of gestational diabetes mellitus, providing a new way for the prediction and prevention of the disease.