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IgM肾病系指以免疫荧光下肾小球系膜区IgM沉积为特征的原发性肾小球疾病。IgM肾病多数以肾病综合征起病,少数表现为蛋白尿、单纯血尿或蛋白尿合并血尿。光镜下肾小球可显现基本正常,也可有不同程度的系膜增殖。早期研究认为该病预后良好;目前研究提示,IgM肾病预后不容乐观,随访5～15年,其中7%～39%发展为肾功能不全,6%～36%进展为终末期肾病。因此,应将IgM肾病作为一独立疾病看待,并延长随访观察时间。
IgM nephropathy refers to a primary glomerular disease characterized by IgM deposition of the mesangial area under immunofluorescence. IgM nephropathy most of the onset of nephrotic syndrome, a small number of manifestations of proteinuria, hematuria or proteinuria with hematuria. Glomerular light microscope can be showed under normal, but also have different degrees of mesangial proliferation. Early studies suggest that the prognosis of the disease is good; the current study suggests that the prognosis of IgM nephropathy is not optimistic, followed up for 5 to 15 years, of which 7% to 39% developed renal insufficiency, 6% to 36% progressed to end-stage renal disease. Therefore, IgM nephropathy should be treated as an independent disease and the duration of follow-up should be extended.