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目的 :分析了 36例肺癌患者化疗前后血清中IL - 2和SIL - 2R水平的变化。方法 :采用放射免疫分析法测定患者血清中IL - 2和使用ELISA法测定SIL - 2R含量 ,并与 35名正常健康人作比较。结果 :化疗前IL- 2活性明显低于正常人 ,SIL - 2R水平明显高于正常人 (P <0 .0 1 ) ,化疗后 6个月复发者IL - 2 /SIL - 2R水平持续异常 ,未复发者IL - 2 /SIL - 2R水平恢复正常。结论 :观察肺癌患者免疫功能的变化与患者的病情和预后密切相关。
Objective: To analyze the changes of serum levels of IL - 2 and SIL - 2R in 36 patients with lung cancer before and after chemotherapy. Methods: Serum IL - 2 levels were measured by radioimmunoassay and SIL - 2R levels were measured by ELISA. The levels of IL - 2 were compared with those of 35 normal controls. Results: Before chemotherapy, the activity of IL - 2 was significantly lower than that of normal people, the level of SIL - 2R was significantly higher than that of normal people (P <0.01), IL - 2 / SIL - 2R level continued to be abnormal 6 months after chemotherapy, The level of IL - 2 / SIL - 2R in non - recurrent patients returned to normal. Conclusion: To observe the changes of immune function in patients with lung cancer is closely related to the patient’s condition and prognosis.