药效学尼莫地平系双氢吡啶类钙拮抗剂,对动脉平滑肌有松弛作用。对离体脑血管有特异性作用。哺乳动物试验表明,静脉或腹腔注射或局部应用尼莫地平,对脑动脉均有扩张作用,尤其对直径70～100μm的动脉作用最强。病人进行颅骨手术后,给予尼莫地平10μg/kg(超过10分钟),能直接观察到脑动脉扩张。哺乳动物静脉或腹腔注射尼莫地平每分钟0.1μg/kg,脑动脉血流(CBF)分别增加18%、170%,动脉压无明显降低。口服本品40～80mg或静注15～30mg/kg,蛛网膜下腔出血病人CBF均增加18%,无明显“窃血”现象。蛛网膜下腔出血病人静滴尼莫地平每小 Pharmacodynamics Nimodipine is a dihydropyridine calcium antagonist, relaxation of arterial smooth muscle. Has a specific role in isolated cerebral blood vessels. Mammalian studies have shown that intravenous or intraperitoneal injection or topical application of nimodipine on the expansion of the cerebral artery, especially for the diameter of 70 ~ 100μm artery strongest. Patients undergoing skull surgery, nimodipine 10μg / kg (more than 10 minutes), can be directly observed cerebral artery dilatation. Nimodipine intravenously or intraperitoneally injected 0.1μg / kg per minute, cerebral arterial blood flow (CBF) increased 18%, 170%, no significant decrease in arterial pressure. Oral 40 ~ 80mg of this product or intravenous injection 15 ~ 30mg / kg, CBF in patients with subarachnoid hemorrhage increased by 18%, no obvious “steal” phenomenon. Subarachnoid hemorrhage patient intravenous nimodipine per small