例1 男性,35岁,7yr(年)来因患非典型抑郁症和惊恐发作入院.入院前4mo(月)患者接受阿普唑仑(alprazolam,甲基三唑安定)治疗,剂量递增至8mg/d.入院日停用此药及两种治疗胃溃疡药物——西咪替丁(cimetidine)1200mg/d及甲氧普胺(metoclopramide,胃复安)10mg/d,而给予安定(diazepam)40mg/d,并准备逐渐减量,以了解患者的药物依赖性.次日安定剂量减至30mg/d,于即日晚患者突然出现癫痫大发作.入院前患者无脑外伤、使用过中枢神经系统(CNS)镇静药及抽搐发作 Example 1 Male, 35 years old, 7 yr (years) admitted to hospital for atypical depression and panic attacks. Patients (4 months prior to admission) received alprazolam (methylprednisolone) in doses up to 8 mg / d. The drug was discontinued on admission day and the two drugs for treatment of gastric ulcer - cimetidine 1200 mg / d and metoclopramide metoclopramide 10 mg / d were given diazepam (diazepam) 40mg / d, and ready to taper to understand the patient’s drug dependence.The next day’s dose was reduced to 30mg / d, sudden onset of epileptic seizures in patients with no brain injury before admission, the use of the central nervous system (CNS) sedatives and seizures