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目的应用新概念———全身炎症反应综合征（ＳＩＲＳ）和多器官功能不全综合征（ＭＯＤＳ）认识多器官功能衰竭（ＭＯＦ）。方法回顾性总结分析１９９５年１月～１９９７年１２月我院儿科加强监护病房收治的危重患儿，根据Ｈａｙｄｅｎ修订的ＳＩＲＳ诊断标准和全国小儿急诊学组拟定的ＭＯＦ诊断标准进行临床分析。结果全组３０４例患儿，符合ＳＩＲＳ标准２５２例，占８２．９％．原发病有感染性疾病和非感染性疾病。在ＳＩＲＳ和ＭＯＤＳ病程发展过程中部分患儿出现一过性肝、肾、胃肠道和脑等器官功能受损的表现，最终进展为ＭＯＤＳ共６５例，占２５．８％。ＭＯＤＳ的病死率为４３．１％（２８／６５）。发生ＭＯＤＳ的高危因素为入院危重评分＜７５分，明显高代谢反应和合并Ｃ反应蛋白，而与年龄无明显关系。结论ＳＩＲＳ和ＭＯＤＳ是小儿加强医疗病房中常见病症，病死率较高。ＳＩＲＳ和急诊学组制定的ＭＯＦ诊断标准简单实用，但应根据美国胸科协会和危重病医学会倡议将ＭＯＦ更名为ＭＯＤＳ。ＳＩＲＳ和ＭＯＤＳ进展至器官功能衰竭前存在器官功能受损的表现，应予高度重视并早期干预。
Objective To apply the new concepts of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) to recognize multiple organ failure (MOF). Methods Retrospective analysis of January 1995 to December 1997 in our hospital pediatric intensive care unit admitted to critically ill children, according to Hayden revised SIRS diagnostic criteria and the national pediatric emergency department to develop MOF diagnostic criteria for clinical analysis. Results The whole group of 304 children, in line with SIRS standard 252 cases, accounting for 82.9%. The primary disease has infectious diseases and non-infectious diseases. During the course of SIRS and MODS, some children showed impaired organ function such as liver, kidney, gastrointestinal tract and brain. The final progression was MODS in 65 cases (25.8%). Mortality of MODS was 43.1% (28/65). Risk factors for the occurrence of MODS admission risk score <75 points, significantly higher metabolic reaction and C-reactive protein, but no significant relationship with age. Conclusion SIRS and MODS are the common diseases in pediatric intensive care unit, with high mortality. The MOF diagnostic criteria developed by the SIRS and ED teams are simple and practical, but the MOF should be renamed MODS according to the American Thoracic Society and Critical Care Medicine Initiative. SIRS and MODS progression to organ failure before organ dysfunction performance, should pay close attention to and early intervention.