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目的探讨人微小病毒B19感染与不良妊娠结局的关系。方法计算机检索1999年~2010年中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP-维普)、万方-数字化期刊全文库,并辅以文献追溯的方法,收集国内公开发表的有关人微小病毒B19感染与不良妊娠结局的相关文献。应用RevMan4.2.10软件进行Meta分析。结果将7个研究结果加权合并,累计病例513例,B19DNA阳性率20.5%;累计对照743例,B19DNA阳性率3.8%;合并OR=6.68(95%CI:4.10~10.88)。结论国内人微小病毒B19感染与不良妊娠结局发生有显著关联。
Objective To investigate the relationship between human parvovirus B19 infection and adverse pregnancy outcome. Methods The databases of Chinese Journal Full-text Database (CNKI), Chinese Science and Technology Periodicals Full-text Database (VIP-VIP) and Wanfang-Digitized Periodicals Full-Text Database were searched by computer from 1999 to 2010. The collected data were collected by domestic public Literature Related to Parvovirus B19 Infection and Adverse Pregnancy Outcomes. Meta-analysis was performed using RevMan 4.2.10 software. Results The results of 7 studies were weighted and combined. The cumulative number of cases was 513 cases. The positive rate of B19 DNA was 20.5%. The cumulative control was 743 cases. The positive rate of B19 DNA was 3.8%. The OR was 6.68 (95% CI: 4.10-10.88). Conclusion Domestic B parvovirus infection is associated with adverse pregnancy outcomes.