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目的 观察异丙酚对小白鼠胃肠蠕动功能的影响。方法 48只小白鼠随机平均分为口服生理盐水组 (NO)、口服异丙酚组 (PO)和静注生理盐水组 (NI)、静注异丙酚组 (PI) ,用药量均为0 .0 2 m l/g。分别于口服给药 2 0分、静脉给药 10分后 ,经口灌入亚甲蓝液 0 .2 m l;经 30分后 ,采用颈椎脱臼法将小白鼠处死 ;打开腹腔 ,剪开肠系膜 ,将肠管轻拉成直线 ,以幽门为起点测量 :(1)亚甲蓝在肠管内移动距离 D;(2 )小肠全长 L (幽门～回盲部 )。计算 :移动率 (MR) % =D(cm ) /L (cm)。结果 MR(% )分别为 NO组 8.8± 0 .5 (8.2～ 9.7) ,PO组 19.8± 2 .0 (15 .0～ 2 4.0 ) ,NI组 6 .4± 0 .6 (5 .4～7.5 ) ,PI组 14.7± 1.5 (11.7～ 17.2 ) ;试验组非常显著地高于各自对照组 (P<0 .0 1)。结论 异丙酚无论口服还是静注 ,对小白鼠胃肠道蠕动都具有一定促进作用。
Objective To observe the effect of propofol on gastrointestinal peristalsis in mice. Methods Forty-eight mice were randomly divided into three groups: oral administration of normal saline (NO), oral propofol group (PO) and intravenous injection of normal saline (NI), intravenous propofol group (PI) .0 2 ml / g. Respectively, 20 minutes after oral administration, intravenous administration of 10 minutes after oral administration of methylene blue liquid 0.2 ml; after 30 minutes, the mice were sacrificed by cervical dislocation; open the abdominal cavity, cut the mesentery, Light bowel into a straight line to the pylorus as a starting point to measure: (1) methylene blue in the intestine to move the distance D; (2) the total length of the small intestine L (pylorus ~ ileocecal Department). Calculation: Mobility (MR)% = D (cm) / L (cm). Results MR (%) were respectively 8.8 ± 0.5 (8.2-9.7) for NO group, 19.8 ± 2.0 (15.0-240) for PO group, 6.4 ± 0.6 for NI group 7.5), PI group 14.7 ± 1.5 (11.7 ~ 17.2); the experimental group was significantly higher than the respective control group (P <0.01). Conclusion Propofol, whether orally or intravenously, can promote gastrointestinal motility in mice.