Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR sig

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：wa0002

【摘要】

：

Cellular metabolism has been shown to regulate differentiation and function of immune cells.Tumor associated immune cells undergo phenotypic and functional alte

【作者】

：

Di Xie Shasha Zhu Li Bai

【机构】

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CASKeyLaboratoryoflnnatelmmunityandChronicDisease,InnovationCenterforCellSignalingNetwork

【出处】

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中国科学：生命科学英文版

【发表日期】

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2016年12期

【基金项目】

：

Acknowledgements We thank Dr. S.L. Liu （USTC） for the kind gifts of MDAMB231 cells, HCC1954 cells, BT474 cells, and Dr. Z.G. Tian （USTC） for B16F10 cells and Dr. Steven A. Porcelli （Albert Einstein Co

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Cellular metabolism has been shown to regulate differentiation and function of immune cells.Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments.NKT cells are good

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Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR sig

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