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目的:探讨肺炎衣原体感染与青少年I型糖尿病的相关性,为I型糖尿病的的临床治疗提供参考依据。方法:选择2010年12月-2012年6月间石家庄地区各医院收治的49例青少年T1DM患者为观察组,及同期50例健康人作为对照组,应用即时指尖血免疫测定仪分析受试者HbA1c水平;应用RT-PCR技术检测血液中Cpn DNA;应用ELISA方法检测受试者血清中Cpn特异性抗体水平,对Cpn DNA的检出情况及HbA1c水平与Cpn DNA和特异性抗体水平的相关性进行统计学分析。结果:观察组Cpn DNA的检出率为46.9%,显著高于对照组(P<0.05);观察组Cpn抗体阳性率显著高于对照组(P<0.05),且观察组再次感染或慢性感染Cpn的百分率显著高于对照组(P<0.05);HbA1c与IgG/IgA抗体水平显著相关,血糖控制较差(HbA1c>9%)的糖尿病患者Cpn IgG/IgA抗体阳性率与血糖控制较好的患者(HbA1c<7%)相比显著升高(P<0.05)。结论:与健康对照相比,青少年T1DM患者更容易感染Cpn,且更容易由急性感染状态进展为慢性感染形式,良好的血糖可能降低患者发生与代谢控制有关的慢性并发症。
Objective: To investigate the relationship between Chlamydia pneumoniae infection and adolescent type I diabetes, and to provide a reference for the clinical treatment of type I diabetes mellitus. Methods: Forty-nine adolescent patients with T1DM admitted to hospitals in Shijiazhuang from December 2010 to June 2012 were selected as the observation group and 50 healthy people as control group. The blood samples were collected from the patients The levels of Cpn DNA in blood were detected by RT-PCR. The level of Cpn DNA in serum was detected by ELISA. The correlation between Cpn DNA level and HbA1c level and Cpn DNA and specific antibody level Statistical analysis. Results: The detection rate of Cpn DNA in observation group was 46.9%, which was significantly higher than that in control group (P <0.05). The positive rate of Cpn antibody in observation group was significantly higher than that in control group (P <0.05) Cpn was significantly higher than that of the control group (P <0.05); HbA1c was significantly associated with IgG / IgA antibody level, and the positive rate of Cpn IgG / IgA antibody in diabetic patients with poor blood glucose control (HbA1c> 9% Patients (HbA1c <7%) were significantly higher (P <0.05). CONCLUSIONS: Adolescents with T1DM are more susceptible to Cpn infection than healthy controls and are more likely to develop chronic infection from acute infection, and good glucose levels may reduce chronic metabolic complications in their patients.