本文作者研究了氯普马嗪的口腔粘膜吸收作用。氯普马嗪的药理和应用近来研究较多,但多偏重于其定量、吸收及体内分布方面而还没有口腔粘膜吸收应用方面的。本文通过测定其镇痛效果、脑中分布量、抑制阿朴吗啡(以下简称APO—M)呕吐作用等研究了口服粘膜吸收情况,并用皮下注射、口服等给药方法进行了吸收比较。实验动物是用大白鼠和田 The authors studied the oral mucosal absorption of chloropimazine. The pharmacology and applications of chloropimazine have been more studied recently, but more emphasis is placed on the application of oral mucosal absorption in terms of its ration, absorption and in vivo distribution. In this paper, the absorption of oral mucosa was studied by measuring the analgesic effect, the distribution in the brain and the inhibition of apomorphine (APO-M) vomiting, and compared with the absorption by subcutaneous injection and oral administration. Experimental animals are rats Wada