论文部分内容阅读
目的:观察敷和备化方防治原发性肝癌介入术后肝纤维化的临床疗效。方法:将80例符合入选标准的原发性肝癌患者随机分为治疗组和对照组各40例。两组均接受3次肝动脉化疗栓塞(TACE)治疗,治疗间歇为1个月。治疗组同时服用敷和备化方治疗。所有患者在行TACE治疗前24h及第3次治疗后1个月,检测肝功能、血清肝纤维化指标(HA、LN、Ⅳ-C、PCⅢ)、细胞因子(TGF-β1、TNF-α),彩超检查门静脉、脾静脉内径和脾脏厚度。结果:两组治疗后肝功能较治疗前明显改善(P<0.05),且治疗组的改善程度明显优于对照组(P<0.05);两组治疗后肝纤维化指标均较治疗前增高(P<0.05),但治疗组的升高幅度明显小于对照组(P<0.05);两组治疗后细胞因子均较治疗前下降(P<0.05),且治疗组的下降幅度明显大于对照组(P<0.05);治疗组肝门静脉、脾静脉内径均明显减小,脾脏厚度明显变薄,作用明显优于对照组(P<0.05)。结论:敷和备化方具有防治原发性肝癌介入术后肝纤维化作用,其机制可能与调控TGF-β1、TNF-α水平有关。
Objective: To observe the curative effect of Fufubaihua Recipe in preventing and treating hepatic fibrosis after interventional operation of primary liver cancer. Methods: Eighty patients with primary liver cancer who met the inclusion criteria were randomly divided into treatment group and control group, 40 cases each. Both groups received three times of TACE, and the treatment interval was 1 month. Treatment group while taking Fu and prepare the side treatment. All patients were tested for liver function, serum levels of hepatic fibrosis (HA, LN, Ⅳ-C, PCⅢ) and cytokines (TGF-β1, TNF-α) 24h before TACE treatment and one month after the third treatment. , Color Doppler ultrasound examination of portal vein, splenic vein diameter and spleen thickness. Results: The liver function of the two groups after treatment was significantly improved (P <0.05), and the improvement in the treatment group was significantly better than that in the control group (P <0.05). The indexes of liver fibrosis in both groups were significantly higher than those before treatment (P <0.05), but the increase in the treatment group was significantly less than that in the control group (P <0.05). The cytokines in both groups were significantly lower than those before treatment (P <0.05), and the decrease in the treatment group was significantly greater than that in the control group P <0.05). The diameters of hepatic portal vein and splenic vein in the treatment group were significantly reduced, and the thickness of the spleen thinned obviously, which was significantly better than that of the control group (P <0.05). Conclusion: Fu-Hebian Recipe has the preventive and therapeutic effects on hepatic fibrosis after interventional chemotherapy of primary hepatocellular carcinoma, which may be related to the regulation of TGF-β1 and TNF-α.