下表列出46个癌基因的位置。其中20个己精确定位在染色体的某一条带上,在这20个癌基因中又有20%定位在特殊的亚带。这样在人类高分辨核型中仅有9%(4/45)的癌基因定位在亚带。另外,57%(26/40)癌基因定位在多带区,这些区域多数都很大,这种不确切的区段是研究的严重障碍。其它91%(42/46)的癌基因仍有可能位于亚带,这就迫切需要用癌基因探针与染色体进行原位杂交,以精确定位这些位点。 The following table lists the locations of 46 oncogenes. Twenty of them have been precisely located on a certain band of the chromosome, and 20% of the 20 oncogenes are located in a special sub-band. Thus only 9% (4/45) of the oncogenes in the human high resolution karyotype are located in the subband. In addition, 57% (26/40) of the oncogenes are located in multiple bands, and most of these areas are large, and this inaccurate segment is a serious obstacle to the study. The other 91% (42/46) of the oncogenes are still likely to be located in the sub-bands, which makes it imperative to use in situ hybridization of oncogene probes to chromosomes to pinpoint these sites.