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甲苯磺丁脲球晶的制备:试验选用的附加剂有HPMC(羟丙基甲基纤维素)、POE 40(聚氧乙烯单硬脂酸酯40)、HCO(氢化蓖麻油)和CMC(羧甲基纤维素),在水溶液中的浓度为0.01、0.04、0.1、0.4和2%。先将20%甲苯磺丁脲的NaOH溶液25 ml和附加剂水溶液250ml置500ml烧杯内混匀,再在600rpm搅拌下加1MHCl中和并使甲苯磺丁脲结晶,然后以每分钟10ml速度加入适量乙醚使结晶聚集,在25°±1℃继续搅拌40分钟即可。甲苯磺丁脲球晶的颗粒大小和溶出速率:附加剂浓度为0.04～2%可得到直径为
Preparation of tolbutamide urea spherulites: The test selected additives were HPMC (hydroxypropyl methylcellulose), POE 40 (polyoxyethylene monostearate 40), HCO (hydrogenated castor oil) and CMC (carboxymethyl Cellulose) at 0.01, 0.04, 0.1, 0.4 and 2% in aqueous solution. First 20% toluene sulfobetaine NaOH solution 25 ml and 250 ml of aqueous solution of anadditives set 500ml beaker mix, and then stirred at 600rpm 1MHCl neutralization and tolbutamide, and then at a rate of 10ml per minute, adding the right amount Ether to crystallize the aggregate, stirring was continued for 40 minutes at 25 ° ± 1 ℃. Tolbutamide urea spherulites particle size and dissolution rate: additive concentration of 0.04 ~ 2% can be obtained with a diameter of