Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism. Methods: Ninety one repeatedly recurrent CPN patients were randomly divided into 2 groups, the control group (45 cases) treated with sufficient amount of sensitive antibiotics and other WM, the treated group (46 cases) treated with above mentioned WM complemented with TCM syndrome differentiation (SD). Results: In the treated group completely cured was 14 cases (30.4%), markedly effective 14 cases (30.4%), the total effective rate was 91.3%; while that of the control group was 4 (8.9%), 5 (11.1%), and 48.9% respectively, ( P < 0.05 ) and ( P <0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6±12.6 days and 24.3±11.5 days, obviously shorter than those of the control group (35.6±14.6 days and 53.6±16.4 days), P <0.01; the various symptoms of the treated group improved or disappeared in a short time, while in the control group a few patients improved in a longer period ( P <0.01); the various immune parameters improved in the treated group, while in the control group only IgA was elevated to some extent ( P <0.05), in comparing these data, the difference was significant ( P <0.01). Conclusion: The TCM WM integrative treatment could obviously raise the clinical efficacy, accelerate the symptom improvement, and enhance the immune function. Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism. Methods: Ninety one repeatedly recurrent CPN patients were randomly divided into 2 groups, the control group ( 45 cases) treated with sufficient amount of sensitive antibiotics and other WM, the treated group (46 cases) treated with mentioned above (30.4%) WM complemented with TCM syndrome differentiation , markedly effective in 14 cases (30.4%), the total effective rate was 91.3%; while that of the control group was 4 (8.9%), 5 (11.1%), and 48.9% respectively <0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6 ± 12.6 days and 24.3 ± 11.5 days, obviously shorter than those of the control group (35.6 ± 14.6 days and 53.6 ± 16.4 days) P <0.01; the va rious symptoms of the treated group improved or disappeared in a short time, while in the control group a few patients improved in a longer period (P <0.01); the various immune parameters improved in the treated group, while in the control group only IgA the comparison of the data, the difference was significant (P <0.01). Conclusion: The TCM WM integrative treatment could obviously raise the clinical efficacy, accelerate the symptom improvement, and enhance the immune function .