本之采用N—茴香叉—D—葡糖胺(Ⅰ)的C_6羟基选择性磷酸化,然后经溴代中间体(Ⅲ)与2—O—苯甲基—5—氟脲嘧啶—4—O—银盐缩合得到2—O—苯甲基—4—O—(N—茴香叉—3,4—二—O—乙酰—6—二苯磷酸—β—D—葡糖胺基)—5—氟脲嘧啶(Ⅳ)。其中(Ⅲ)、(Ⅳ)是未见报道的新化合物。元素分析、红外光谱、核磁共振谱确定了该化合物的组成及结构,(Ⅲ)为α构型,(Ⅳ)为β构型。 Selective phosphorylation of C 6 hydroxyl with N-anisylidene-D-glucosamine (I) followed by bromination of intermediate (III) with 2-O-benzyl-5-fluorouracil- O-silver salt to give 2-O-benzyl-4-O- (N-anisylidene-3,4-di-O-acetyl-6-diphenylphospho-β-D-glucamine) 5-fluorouracil (IV). Among them, (Ⅲ) and (Ⅳ) are new compounds which have not been reported. The composition and structure of the compound were confirmed by elemental analysis, IR and 1H NMR spectra. (Ⅲ) α configuration, (Ⅳ) β configuration.