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为探讨胃癌单克隆抗原ＭＧ７在胃粘膜不典型增生中的预测价值，应用ＭＧ７抗体进行ＡＢＣ免疫组化染色，并用计算机图象分析系统，对７２例有随访结果的胃粘膜不典型增生标本的ＭＧ７抗原表达进行了定量分析。通过计算约登指数及绘制受试者工作特征曲线，初步探讨了ＭＧ７表达的高危界值。免疫组化染色结果显示，癌变组３４例标本中有２４例表达阳性（７０．６％）。未癌变组３８例标本中仅７例呈阳性表达（１８．４％），两组比较差异有显著性。图象分析等结果显示：ＭＧ７Ａｇ的平均灰度值≥０．１９为高危界值，以此值作为判定不典型增生是否具有癌变倾向的依据，其灵敏度＝８２．４％，特异度＝７８．９％，准确度＝８０．６％。结论：ＭＧ７Ａｇ的表达程度和胃粘膜不典型增生癌变关系密切，ＭＧ７Ａｇ表达阳性的胃粘膜不典型增生病例，尤其是灰度值≥０．１９者，是具有潜在癌变倾向的高危人群，对这些病人进行严密的随访监测，可提高早期胃癌检出率。
To investigate the predictive value of gastric cancer monoclonal antigen MG7 in dysplasia of gastric mucosa, MG7 antibody was used for ABC immunohistochemical staining, and 72 cases of gastric dysplasia MG7 with follow-up results were analyzed by computer image analysis system. Antigen expression was quantified. The high risk threshold of MG7 expression was preliminarily explored by calculating the Youden index and drawing the characteristics of the receiver’s working characteristics. Immunohistochemical staining showed that 24 out of 34 specimens in the cancerous group were positive (70.6%). Among the 38 specimens in the non-cancerous group, only 7 cases were positively expressed (18.4%), and there was a significant difference between the two groups. Image analysis and other results show that the mean gray value of MG7Ag is ≥0.19, which is a high risk cutoff value. This value is used as the basis for judging whether atypical hyperplasia has a cancerous tendency. Its sensitivity is 82.4% and specificity is 78. 9%, accuracy = 80.6%. Conclusion: The expression level of MG7Ag is closely related to the dysplasia of gastric mucosa. The cases of gastric mucosal dysplasia with positive MG7Ag expression, especially those with a gray value of ≥0.19, are high-risk groups with potential cancer tendency. Strict follow-up monitoring can improve the detection rate of early gastric cancer.