目的筛选合并代谢异常的帕金森病模型,为后续的相关实验研究提供理想的动物模型。方法SD雄性大鼠62只,随机分为损毁前脑内侧束(MFB)模型组、损毁MFB假手术组、损毁纹状体模型组和损毁纹状体假手术组。模型制做成功后进行旋转实验,两组大鼠中分别选出成功模型,并分别对两组成功的PD模型大鼠的摄食、体重、血糖和腹腔内脂肪组织进行检测。观察两组模型大鼠上述代谢指标的变化。结果损毁MFB较损毁纹状体制作帕金森病模型的成功率高(70.97%比38.71%)。与各假手术组大鼠相比,MFB模型大鼠既出现体重明显的减轻[(218.1±13.99)g比(252.7±10.1)g,P<0.05],腹腔注射葡萄糖后15min和30min血糖出现了明显升高,并且肾周白色脂肪组织明显减少(左右两侧)。纹状体模型大鼠仅饮食减少[(13.95±0.25)g比(20.23±0.86)g,P<0.001]和腹腔注射葡萄糖后15min、30min和60min时间点血糖升高。结论损毁MFB的PD模型大鼠无论模型成功率还是代谢相关指标都较损毁纹状体的PD模型更接近糖脂代谢异常的PD患者。 Objective To screen the model of Parkinson ’s disease with abnormal metabolism, and to provide an ideal animal model for subsequent related experimental research. Methods Sixty-two male Sprague-Dawley rats were randomly divided into three groups: the injured forebrain bundle (MFB) model group, the MFB sham operation group, the damaged striatum model group and the injured striatum sham operation group. The model was successfully rotated after the experiment, two groups of rats were selected successful model, respectively, and two groups of successful PD model rats feeding, body weight, blood glucose and intra-abdominal fat tissue were detected. The changes of the above metabolic indexes in the two groups of rats were observed. Results The success rate of destroying MFBs was higher (70.97% vs 38.71%) than that of striatum producing Parkinson’s disease model. Compared with sham-operated rats, MFB model rats showed significant weight loss [(218.1 ± 13.99) g vs (252.7 ± 10.1) g, P <0.05]. Glucose appeared at 15 and 30 minutes after intraperitoneal injection of glucose Significantly increased, and perirenal white adipose tissue was significantly reduced (left and right sides). In the striatum model, only diet decreased [(13.95 ± 0.25) g vs (20.23 ± 0.86) g, P <0.001] and blood glucose increased 15, 30 and 60 minutes after intraperitoneal injection of glucose. Conclusions The PD model rats with MFB destruc- tion have a closer success to the PD patients with abnormal glucose and lipid metabolism than those with striatum, regardless of model success rate or metabolic index.