论文部分内容阅读
ACNU是最近试用的亚硝脲类新抗癌剂。作用机制尚未完全阐明,可能是由于烷化作用使DNA低分子化和合成障碍。临床上报告对肺癌、乳腺癌、恶性黑色素瘤、恶性淋巴瘤、白血病等有效。秋田大学第三内科和有关医院自1978年1月至1979年12月二年间治疗恶性淋巴瘤10例,急性白病病9例,慢性粒细胞型白血病急性变3例。恶性淋巴瘤10例中,病理组织学诊断何杰金氏病4例,非何杰金氏淋巴瘤6例,病期是Ⅱ.至Ⅳ_(bo)急性白血病中是急性粒细胞型白血病6例,急性淋巴细胞型白血病1例,红白血病1例,急性早幼粒细胞型白血病1例。
ACNU is the latest trial of new nitrosourea anti-cancer agent. The mechanism of action has not yet been fully elucidated, probably due to the alkylation of DNA to lower molecular and synthetic barriers. Clinically reported on lung cancer, breast cancer, malignant melanoma, malignant lymphoma, leukemia and so effective. Akita University Third Medical and related hospitals from January 1978 to December 1979 two years of treatment of malignant lymphoma in 10 cases, 9 cases of acute leukemia, acute myeloid leukemia in 3 cases. In 10 cases of malignant lymphoma, pathological diagnosis of Hodgkin’s disease in 4 cases, non-Hodgkin’s lymphoma in 6 cases, the disease stage is Ⅱ. To Ⅳ bo acute leukemia is acute myeloid leukemia in 6 cases 1 case of acute lymphocytic leukemia, 1 case of erythroleukemia and 1 case of acute promyelocytic leukemia.