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葡萄球菌肠毒素是一组由金黄色葡萄球菌产生的结构上相关、血清学上不同的蛋白质,其显著特征是:都能刺激小鼠和人的T细胞增殖,并产生淋巴因子。本文作者报道了用葡萄球菌肠毒素A 型(SEA)诱导人外周血T 淋巴细胞和单核细胞明显地产生TNF。剂量反应表明SEA 是一种强有力地TNF 诱导剂,即使浓度不足1pg/ml,亦可诱导TNF 产生,当浓度在1ng/ml 时,TNF 可达到最高水平。对这种TNF 产生的动力学分析证明在第3天出现峰值,于培养的第6天后降低到临界水平。DNA 合成的高峰出现于培养中的第4天。TNF-α(肿瘤坏死因子-α)和TNF-β(淋巴毒素)产生的时间也不
Staphylococcal enterotoxins are a group of structurally related, serologically distinct proteins produced by Staphylococcus aureus and are distinguished by their ability to both stimulate T cell proliferation in mice and humans and produce lymphokines. The authors report that TNF-a was induced significantly by the induction of staphylococcal enterotoxin type A (SEA) in human peripheral blood T lymphocytes and monocytes. The dose response demonstrated that SEA is a potent TNF-inducer that induces TNF production even at concentrations less than 1 pg / ml, with TNF reaching its highest level at 1 ng / ml. Kinetic analysis of this TNF production demonstrated peak on day 3, decreasing to the critical level after day 6 of culture. The peak of DNA synthesis appeared on the 4th day of culture. Neither TNF-α (tumor necrosis factor-α) nor TNF-β (lymphotoxin) produce time