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本文报告了哌仑西平(P)对几种大鼠胃分泌模型的作用。实验表明,P对幽门结扎和多种刺激剂,如氨甲酰胆碱、胰岛素、五肽胃泌素和组织胺所致胃分泌都有不同强度的抑制作用。提示P可望成为很有前途的抗溃疡药物。
This article reports the effect of pirenzepine on several gastric secretion models in rats. Experiments show that P on the pylorus ligation and a variety of stimuli, such as carbachol, insulin, pentagastrin and histamine caused by gastric secretion have different intensity of inhibition. Tip P is expected to be a promising anti-ulcer drug.