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目的研究上皮性钙黏附蛋白(E-cad)和α-连结素(α-Cat)的表达与胃癌生物学行为的关系。方法应用免疫组织化学SABC法分别检测76例胃癌及其相应正常胃黏膜组织中E-cad和α-Cat表达。结果胃癌组织中E-cad和α-Cat阳性表达率分别为46.1%和36.8%,均明显低于相应正常组织(P<0.01)。E-cad表达与胃癌分化程度及生长方式有关(P<0.01),且随着胃癌的分化程度降低,弥漫生长、浸润深度增加以及有淋巴结转移者α-Cat阳性表达率愈低(P<0.05或0.01)。结论E-cad和α-Cat表达下调伴随着胃癌的去分化和弥漫生长,且α-Cat表达异常与胃癌浸润转移密切相关。
Objective To investigate the relationship between the expression of epithelial cadherin (E-cad) and α-catenin (α-Cat) and the biological behavior of gastric cancer. Methods Immunohistochemistry SABC method was used to detect the expression of E-cad and α-Cat in 76 cases of gastric carcinoma and their corresponding normal gastric mucosa. Results The positive rates of E-cad and α-Cat in gastric cancer tissues were 46.1% and 36.8%, respectively, which were significantly lower than those in normal tissues (P<0.01). E-cad expression was correlated with the differentiation degree and growth pattern of gastric cancer (P<0.01), and with the decrease of differentiation of gastric cancer, diffuse growth, invasive depth and the expression of α-Cat in lymph node metastasis were lower (P<0.05). Or 0.01). Conclusion The down-regulation of E-cad and α-Cat is accompanied by the dedifferentiation and diffuse growth of gastric cancer, and the abnormal expression of α-Cat is closely related to the infiltration and metastasis of gastric cancer.