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目前 VC 主要有片剂和注射剂两种剂型,其化学结构决定其具有强还原性,极易被氧化。贮存期间质量极不稳定,而微型胶囊具有使药物与外界环境隔绝,增强稳定性之优点。我们以滴入冻凝法用聚乙二醇2000为包囊材料制备,方法如下:取液体石蜡20克,水浴加热至70℃趁热分次加入司盘600.6克,加聚乙二醇6000 4克及 VC10克,熔化后自水浴中取出,搅拌至形成均匀的分散物,加冷石油醚40ml,搅拌至聚乙二醇凝固成微囊,过滤分离,然后用石油醚洗涤,自然干燥即得。用此法制 VC 微囊的过程中应注意以下几点:(1)搅拌速度要均匀,一般以
Currently VC mainly tablets and injections two formulations, its chemical structure determines its strong reducibility, easily oxidized. The quality is extremely unstable during storage, while microcapsules have the advantage of isolating the drug from the external environment and enhancing the stability. We drop to freeze coagulation method using polyethylene glycol 2000 as encapsulation material, as follows: Take liquid paraffin 20 grams, heated to 70 ° C in a water bath to heat Division added 600.6 grams, add polyethylene glycol 6000 4 Grams and VC10 grams, taken out of the water bath after melting, stirring to form a uniform dispersion, add cold petroleum ether 40ml, stirring until polyethylene glycol coagulation into microcapsules, filtration and separation, and then washed with petroleum ether, natural drying that . With this legal VC microcapsule process should pay attention to the following points: (1) stirring speed to be uniform, generally