【摘 要】
：
Hand, foot, and mouth disease (HFMD) is an infectious disease caused by various enterovirus (EV) serotypes and occurs in infants and children across the world. The mild symptoms of HFMD include fever and a maculopapular rash on the hands, feet, mouth, and
【机 构】
：
Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China
论文部分内容阅读
Hand, foot, and mouth disease (HFMD) is an infectious disease caused by various enterovirus (EV) serotypes and occurs in infants and children across the world. The mild symptoms of HFMD include fever and a maculopapular rash on the hands, feet, mouth, and buttocks. However, in some patients, this infection causes severe neurological syndromes and even death. EVs belong to the Enterovirus genus (family Picornaviridae, order Picornavirales), of which there are 15 species: Enterovirus A (EV-A), EV-B, EV-C, EV-D, EV-E, EV-F, EV-G, EV-H, EV-I, EV-J, EV-K, EV-L, Rhinovirus A, Rhinovirus B, and Rhinovirus C. Since the 2008 outbreaks, enterovirus 71 (EV-A71) and coxsackievirus A16 (CVA16) have been considered to be the two major HFMD pathogens in China[1]. Nevertheless, other prevalent EV serotypes have caused large-scale outbreaks (e.g., CVA4, CVA6, CVA10, and Echovirus 11). Therefore, increasing attention has recently shifted to other EV-A and EV-B pathogens to determine the spectrum of HFMD-causing pathogens besides the major causative ones.
其他文献
目的:探讨地塞米松鼓室内注射联合碳酸氢钠静注治疗内耳眩晕的临床效果.方法:选取2017年3月～2018年3月本院收治的92例内耳眩晕患者,通过随机数字表法分为常规组(n=46)与观察组(n=46).常规组给予碳酸氢钠静注等常规药物治疗,观察组在常规组基础上给予地塞米松鼓室内注射.对比两组治疗效果、治疗前、治疗12d后眩晕程度、听阈水平.结果:观察组总有效率97.83％(45/46),高于常规组的78.26％(36/46)(P<0.05);治疗12d后观察组眩晕缓解有效率95.65％(44/46),高于常规
Type-VI secretion system (T6SS) is a widespread bacteriophage-like complex in bacteria that participates in multiple physiological processes, including metal ion uptake, bacterial competition, and biofilm formation[1]. Yersinia pestis is the causative age
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. It accounts for 8％–10％ of all malignant tumors in children[1] and results in a heavy burden to the life and health of children. NB is a complex disease, and its occurrence is rel
Objective To develop effective alternatives to natural enzymes, it is crucial to develop nanozymes that are economical, resource efficient, and environmentally conscious. Carbon nanomaterials that have enzyme-like activities have been extensively develope
Objective To explore associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cardiovascular events in a Chinese population, with a long-term follow-up. Methods A random sample of 2,031 participants (73.6％ males, mean age = 6
The main transmission routes of Coronavirus Disease 2019 (COVID-19) include droplet and contact transmission. Airborne transmission may be possible in specific circumstances and settings in which aerosol-generating procedures are performed[1]. In 2020, mo
目的:探究磷酸奥司他韦治疗儿童甲型、乙型流行性感冒临床疗效及对炎性因子水平的影响.方法:选取2019年11月～2020年01月本院收治甲型、乙型流行性感冒患儿100例,根据咽拭子胶体金法检测结果可分为甲型流感组74例,乙型流感组26例.比较甲型、乙型流行性感冒患儿经磷酸奥司他韦治疗后临床疗效以及炎性因子水平变化.结果:甲型流感组的治疗有效率显著高于乙型流感组,差异具有统计学意义(P<0.05).治疗后,两组的TNF-α、IL-6、CRP水平显著低于治疗前的水平(P<0.05),甲型流感组的TNF-α、IL
目的:分析乙型肝炎病毒(HBV)相关慢加急性肝衰竭(HBV-ACLF)患者血清甲胎蛋白(AFP)水平变化及患者疾病转归的关系.方法:选取2018年1月～2020年1月本院HBV-ACLF患者109例,入院后抽取血液样本,经全自动电化学发光分析仪测定AFP水平,并给予对应治疗.统计不同疾病分期、不同预后患者血清AFP水平,分析血清AFP水平与疾病预后关联性.结果:不同疾病分期HBV-ACLF患者血清AFP水平间存在显著差异(P<0.05),中期患者血清AFP水平低于早期患者(P<0.05),晚期患者血清AF
目的:探讨右美托咪定联合罗哌卡因竖脊肌平面阻滞(ESPB)在多发性肋骨骨折术后镇痛中的效果.方法:选取本院2019年4月～2021年3月收治的多发性肋骨骨折患者118例,采用随机数字表法分成观察组和对照组,每组各59例.对照组术后采用超声引导下前锯肌平面阻滞(SAPB)镇痛,使用0.375％罗哌卡因注射液20 mL进行局部浸润,观察组使用0.5μg/kg右美托咪定+0.375％罗哌卡因20 mL进行ESPB.比较两组术后4h、12h、24h的静态、咳嗽疼痛评分和不良反应发生情况.结果:观察组术后4h、12
目的:探究凝血四项与老年重症肺炎(Severe Pneumonia,SP)疾病转归的相关性.方法:选取本院86例老年SP患者(2019年1月～2020年3月)作为观察组,再选取同期84例老年非SP患者作为对照组.比较两组凝血四项指标[凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、活化部分凝血酶时间(APTT)]水平、不同转归患者凝血四项水平、分析老年SP疾病转归与PT、APTT、TT、FIB水平与的相关性.结果:观察组FIB低于对照组,PT、APTT、TT高于对照组(P<0.05);86