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目的探讨参附注射液治疗脓毒症休克(阳脱证)患者的临床疗效和安全性。方法选取脓毒症休克(阳脱证)患者80例作为研究对象,随机分为观察组和对照组各40例,对照组予常规治疗,观察组在常规治疗的基础上加用参附注射液,于用药24 h后观察并比较2组患者APACHEⅡ评分、中医证候积分、血流动力学、尿量、血乳酸浓度和乳酸清除率等指标及用药安全情况。结果观察组治疗后APACHEⅡ评分较治疗前和对照组治疗后均下降明显,差异有统计学意义(P<0.05)。观察组中医证候积分总有效率85.0%,对照组为65.0%,差异有统计学意义(P<0.05)。观察组治疗后血流动力学指标较治疗前明显改善,差异有统计学意义(P<0.05);且疗效优于对照组,差异亦有统计学意义(P<0.05)。观察组治疗后尿量增加,血乳酸浓度降低,乳酸清除率提高,与对照组比较差异有统计学意义(P<0.05)。结论应用参附注射液治疗脓毒症休克(阳脱证)具有临床价值。
Objective To investigate the clinical efficacy and safety of Shenfu injection in the treatment of septic shock (Yangxie card) patients. Methods Seventy patients with septic shock (Yangxie Syndrome) were selected as study subjects and randomly divided into observation group and control group, 40 cases in each group. The control group was given routine treatment. The observation group was treated with Shenfu Injection After 24 h, the APACHE Ⅱ score, TCM syndrome score, hemodynamics, urine output, blood lactate concentration and lactic acid clearance were observed and compared in two groups. Results APACHE Ⅱ score in observation group decreased significantly after treatment compared with that before treatment and control group, the difference was statistically significant (P <0.05). The total effective rate of TCM syndromes in observation group was 85.0% and that in control group was 65.0%, the difference was statistically significant (P <0.05). The hemodynamic indexes in the observation group were significantly improved after treatment compared with before treatment, the difference was statistically significant (P <0.05); and the effect was better than the control group, the difference was also statistically significant (P <0.05). After treatment, the observation group increased urine output, blood lactate concentration decreased, lactic acid clearance increased, compared with the control group, the difference was statistically significant (P <0.05). Conclusion Shenfu injection in the treatment of septic shock (Yang Xie card) has clinical value.