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目的 :通过研究抗湿热胶囊对热损伤大鼠 β -内啡肽 (β -EP)的影响 ,探究其抗热损伤的作用机制。 方法 :采用人工气候箱制成高温高湿环境 ,造成热损伤模型 ,测定大鼠下丘脑、垂体、血浆中 β -EP、的含量。 结果 :大鼠在受热后血浆和下丘脑中 β-EP的含量均升高 ,而垂体中 β -EP含量显著降低 ;给药组大鼠热损伤后血浆和下丘脑中 β -EP的含量高于模型组 (P <0 .0 5 )。结论 :抗湿热胶囊能明显提高热损伤大鼠血浆和下丘脑中 β -EP的含量 ,同时具有延缓垂体内 β -EP的水平下降的趋势 ,而高温反应中 ,β-EP能减轻热和疼痛刺激所致的生理反应 ,由此可以认为 ,抗湿热胶囊其机制可能是通过血浆和下丘脑中的 β -EP发挥作用 ,来提高机体的耐受力 ,减轻热损伤
OBJECTIVE : To investigate the effect of anti-moist heat capsules on β-endorphin (β-EP) in heat-damaged rats and explore the mechanism of heat-damage injury. Methods : A high-temperature and high-humidity environment was created by artificial climate chamber, which caused a thermal injury model. The contents of β-EP in the hypothalamus, pituitary and plasma were measured. RESULTS: After the rats were heated, the content of β-EP in plasma and hypothalamus increased, but the content of β-EP in pituitary was significantly decreased. The content of β-EP in plasma and hypothalamus was high after heat injury in rats in the administration group. In the model group (P < 0.05). Conclusion: The anti-humid-heat capsule can significantly increase the β-EP content in the plasma and hypothalamus of heat-damaged rats and delay the decrease of β-EP levels in the pituitary. However, β-EP can reduce heat and pain in hyperthermia reactions. The physiological reaction caused by stimulation can be considered that the mechanism of anti-humidity and heat-resistant capsules may be through plasma and hypothalamic β-EP to increase the body’s tolerance and reduce thermal damage.