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目的:探讨纤溶酶原酶激活因子(uPA)、纤溶酶原酶激活因子受体(uPAR)、nm23-H1基因在子宫内膜癌(endometrial carcinoma,EC)及子宫内膜病变中的表达,研究uPA、uPAR和nm23-H1对EC侵袭转移及预后的影响。方法:采用免疫组化技术检测45例原发性EC和26例子宫内膜增殖症、12例子宫内膜不典型增生中uPA、uPAR和nm23-H1基因的表达情况。结果:uPA、uPAR在EC的腺体细胞中表达最强,差异有统计学意义(P<0.05);nm23-H1在EC与子宫内膜增生组之间差异有统计学意义(P<0.05);在EC手术标本中,uPA、uPAR随组织学分级的增高浸润深度的增加,淋巴结的转移显著升高,nm23-H1呈低表达。结论:EC组织中uPA、uPAR的高表达及nm23-H1的低表达与子宫内膜癌的发生、发展及浸润转移有关,并且与疾病发展、预后有关。
Objective: To investigate the expression of uPA, uPAR and nm23-H1 in endometrial carcinoma (EC) and endometrial lesions To study the effects of uPA, uPAR and nm23-H1 on the invasion, metastasis and prognosis of EC. Methods: Immunohistochemistry was used to detect the expression of uPA, uPAR and nm23-H1 in 45 cases of primary EC and 26 cases of endometrial hyperplasia and 12 cases of endometrial dysplasia. Results: The expression of uPA and uPAR was the highest in EC glandular cells with statistical significance (P <0.05). The difference of nm23-H1 between EC and endometrial hyperplasia group was statistically significant (P <0.05) In EC specimens, uPA and uPAR increased with the increase of histological grade, lymph node metastasis and nm23-H1 expression were low. Conclusion: The high expression of uPA and uPAR in EC tissue and the low expression of nm23-H1 are associated with the occurrence, development and invasion and metastasis of endometrial carcinoma, and are related to the development of disease and prognosis.