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为观察静脉化疗及腹腔化疗对细胞免疫的影响，选择较好的化疗方案，自１９９４年起，连续对１８例大肠癌根治术后早期静脉化疗及２１例腹腔化疗病人进行观察，行５－Ｆｕ加左旋咪唑方案化疗。通过化疗前后抽血检查Ｔ细胞亚群比例及ＮＫ细胞比例的变化，发现腹腔化疗组上述指标无明显下降，静脉化疗组下降明显，证明腹腔化疗对细胞免疫抑制较重。认为：腹腔化疗是大肠癌根治术后较为理想的辅助治疗措施
In order to observe the effect of intravenous chemotherapy and intraperitoneal chemotherapy on cellular immunity, a better chemotherapy regimen was chosen. Since 1994, 18 patients with early colorectal cancer after radical resection and 21 patients with intraperitoneal chemotherapy were observed for 5-Fu. Add levamisole regimen chemotherapy. After blood was taken before and after chemotherapy, the proportion of T cell subsets and the proportion of NK cells were examined. It was found that the above indicators in the intraperitoneal chemotherapy group did not decrease significantly, and the intravenous chemotherapy group decreased significantly, demonstrating that the intraperitoneal chemotherapy is more severe in suppressing cellular immunity. It is believed that intraperitoneal chemotherapy is an ideal supplementary treatment for colorectal cancer after radical surgery