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1882年Wiethe描述临床见到62岁女性患者的视乳头有2个小凹,以后类似的病例多为一个小凹并常并有黄斑部改变,包括浆液性脱离、囊样变性或形成破孔。关于视网膜下液的来源认为可能来自黄斑裂孔、脑脊液经过小凹达到视网膜下、房水或液化玻璃体经小凹进入视网膜下间隙等学说。作者研究3只牧羊狗单眼视乳头小凹合并黄斑部浆液性脱离,2只狗另一眼视乳头有小凹但不合并黄斑部脱离,其余一狗另眼正常。眼底见黄斑部脱离范围为3～6PD,与视乳头小凹近侧
In 1882, Wiethe described the clinical observation of 62-year-old female patients with 2 small concave papillae, after more than a case of mostly a small concave and often macular degeneration, including serous detachment, cystic degeneration or the formation of holes. About the origin of subretinal fluid that may come from the macular hole, cerebrospinal fluid after the subfoveal reached the retina, aqueous humor or liquefied vitreous into the subfoveal space through the small gap theory. The authors studied three sheepskin monocular papilledema and macular serous detachment, the other two dogs with papillae concave but not associated with macular detachment, the rest of a dog the other eye is normal. Macular see the fundus from the scope of 3 ~ 6PD, and the optic disc near the concave