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选用日本白兔60只，随机分为A、B、C三组，每组20只。A组为单纯变态反应疾病组，B组为变态反应疾病激素治疗组，C组为正常对照组。A、B两组经耳静脉注射马血清，每次10mg／kg，共两次，间隔3周。B组2周后注射强的松龙45mg／kg，连续3天。C组注射等量生理盐水。观察项目有病理组织学、透射和扫描电镜、血管造影以及免疫组织化学等。结果显示单纯变态反应性疾病即可导致骨坏死发生。应用该激素后抑制了机体的免疫机能，致使免疫复合物沉积在股骨头骨髓内、骨小梁和小血管壁基底膜上，引起微循环结构受损，干扰骨细胞代谢，增加骨坏死发生率。
Sixty Japanese white rabbits were randomly divided into A, B and C groups of 20 rats. Group A was a simple allergic disease group, group B was hormone therapy for allergic diseases, and group C was a normal control group. A, B two groups via the ear vein injection of horse serum, each 10mg / kg, a total of two, an interval of 3 weeks. B group 2 weeks after injection of prednisolone 45mg / kg, for 3 days. Group C was injected with normal saline. Observational projects include histopathology, transmission and scanning electron microscopy, angiography, and immunohistochemistry. The results show that simple allergic disease can lead to osteonecrosis. The hormones inhibit the body’s immune function, resulting in the deposition of immune complexes in the femoral head bone marrow, trabecular bone and small vessel wall basement membrane, causing microcirculation structure damage, interfere with bone cell metabolism, increase the incidence of osteonecrosis .