论文部分内容阅读
目的上皮性钙黏蛋白(E-cad)和nm23-H1在卵巢上皮性癌中的表达及其与卵巢癌侵袭转移的关系。方法采用免疫组化SP法检测33例卵巢上皮性癌,20例卵巢良性上皮性肿瘤和10例卵巢正常组织中E-cad和nm23-H1的表达。结果 E-cad在卵巢癌组织中的阳性表达率(54.5%)明显低于正常组(100.0%)及良性组(65.0%)(P均﹤0.05);nm23-H1在卵巢癌组织中的阳性表达率(66.7%)明显低于正常组(90.0%)及良性组(85.0%)(P均﹤0.05);E-cad和nm23-H1的阳性表达与卵巢癌临床分期、组织分级和淋巴转移有关(P<0.05);在卵巢癌组织中E-cad与nm23-H1呈正相关关系。结论 E-cad及nm23-H1与卵巢癌的发生、发展和侵袭转移有关,是评估预后的有效指标;E-cad与nm23-H1在卵巢癌中表达呈正相关,在卵巢癌发生发展中可能存在协同效应。
Objective To investigate the expression of epithelial cadherin (E-cad) and nm23-H1 in epithelial ovarian cancer and its relationship with the invasion and metastasis of ovarian cancer. Methods Immunohistochemical SP method was used to detect the expression of E-cad and nm23-H1 in 33 cases of ovarian epithelial carcinoma, 20 cases of ovarian benign epithelial tumor and 10 cases of normal ovarian tissue. Results The positive rate of E-cad in ovarian cancer (54.5%) was significantly lower than that in normal group (100.0%) and benign group (65.0%) (P <0.05). The positive rate of nm23-H1 in ovarian cancer The positive rates of E-cad and nm23-H1 were significantly correlated with the clinical stages, histological grade and lymphatic metastasis of ovarian cancer (66.7%) than those in normal group (90.0%) and benign group (85.0% (P <0.05). There was a positive correlation between E-cad and nm23-H1 in ovarian cancer. Conclusions E-cad and nm23-H1 are correlated with the occurrence, development and invasion and metastasis of ovarian cancer, which are effective indicators for evaluating the prognosis. E-cad and nm23-H1 are positively correlated with the expression of nm23-H1 in ovarian cancer and may be present in the development and progression of ovarian cancer Synergy.