成骨不全症比较少见,现将我院遇到的5例及家系调查报告如下: 患儿,男,2岁。因反复骨折就诊。第2胎2产,足月顺产。生后11个月开始出牙,12月能独自站立,18个月开始独立行走。生后1月家长给患儿穿换衣服时导致右肱骨骨折。此后分别于6个月、16个月、21个月先后发生四次病理性骨折。其父亲、姑母、祖母、曾外祖父均为兰巩 Osteogenesis imperfecta is relatively rare, now our hospital encountered 5 cases and pedigrees reported as follows: Children, male, 2 years old. Due to repeated fracture treatment. 2 births 2, full-term birth. Teething begins 11 months after birth, standing alone in December and walking independently for 18 months. Parents in January to wear clothes to the children lead to fracture of the right humerus. Since then, four pathological fractures occurred successively in 6 months, 16 months and 21 months respectively. His father, aunt, grandmother and grandfather were grandiose