血红素氧合酶是催化血红素降解为一氧化碳(CO)、胆绿素和铁的限速酶,有着广泛的生物学功能。在人类胎盘滋养细胞、血管内皮细胞和平滑肌细胞上均有表达,有助于增加子宫和胎儿胎盘血流、参与螺旋动脉的转化和绒毛血管的发育,并能保护胎盘组织细胞免受氧化损伤。进一步深入了解其在胎盘中的作用和调控机制,可能对病理妊娠的防治具有重要意义。 Heme oxygenase is a rate-limiting enzyme that catalyzes the degradation of heme to carbon monoxide (CO), biliverdin and iron, and has a wide range of biological functions. It is expressed in human placental trophoblasts, vascular endothelial cells and smooth muscle cells. It helps to increase uterine and fetal placental blood flow, participates in the conversion of spiral arteries and villus development, and protects placental cells from oxidative damage. Further understanding of its role in the placenta and the regulatory mechanism may be of great significance in the prevention and treatment of pathological pregnancy.