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胃黏膜的肠上皮化生 (intestinalmetaplasia ,IM ) ,作为Correa’s的胃癌发生多步骤假设的中间步骤 ,已被视为癌前病变。 1883年Kuppffer首先在胃黏膜内发现了类似肠上皮的结构 ;195 5年Marson提出肠化生与胃癌有关 ;196 6年Lauren将胃癌分为肠型与弥漫型两类 ,并认为肠化生与
Gastric mucosa intestinal metaplasia (IM), as an intermediate step in the multi-step hypothesis of Correa’s gastric cancer, has been considered as a precancerous lesion. 1884 Kuppffer first found in the gastric mucosa similar to the structure of the intestinal epithelium; 195 5 Marson proposed intestinal metaplasia and gastric cancer; 196 6 Lauren will be divided into intestinal type and diffuse gastric two types, and that intestinal metaplasia and