羰基化合物具有很好的反应性能,常用作合成原料或关键中间体。长期以来,研究羰基化合物的不同制备方法,一直是有机化学的一个重要课题。众所周知,Friedel-Crafts反应是将羰基直接引入芳环的一种重要方法。由于芳环富电,故要求酰化剂缺电,即为亲电反应。由此可以推测,如果要在缺电基质上引入酰基,则需要一种亲核的酰基化试剂。由于缺乏稳定因素,酰基负离子仅能作为一种概念性的分子碎片而存在。亲核酰化反应实际上是通过酰基负离子的等价基团实现的。这种等价基具有两重性,一是可以进攻 Carbonyl compounds have good reactivity, often used as synthetic raw materials or key intermediates. For a long time, studying different preparation methods of carbonyl compounds has been an important topic in organic chemistry. It is well-known that Friedel-Crafts reaction is an important method to introduce carbonyl directly into the aromatic ring. As the aromatic ring rich, it is required power acylating agent, that is electrophilic reaction. From this it can be speculated that if an acyl group is to be introduced onto a lacking substrate, a nucleophilic acylating reagent is needed. Due to the lack of stabilizing factors, acyl anions can only exist as a conceptual molecular fragment. The nucleophilic acylation reaction is actually achieved by the equivalent group of acyl anion. This equivalence base has dual nature, one can attack