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采用自制的光活化实验装置 ,测定了 11个合成的多炔类化合物对致倦库蚊Culexquinque fasciatus 4龄幼虫的光活化毒力 ,发现部分化合物在近紫外光照射条件下 ,能明显地提高光活化毒杀效应 ,测得化合物 5(1 苯基 4 (3,4 亚甲基二氧 )苯基 丁二炔 )光照与未光照处理LC50 分别是0 35μg/mL和 8 89μg/mL。实验中发现蚊虫先接触药后 ,再进行光照处理 ,才能较好地发挥毒效 ,而且毒杀效应与光照时间呈正相关。模拟田间试验表明 ,太阳光能显著提高化合物 5毒杀蚊幼虫的药效。利用抗氧化剂进行猝灭作用试验 ,间接地证明化合物 5的光活毒杀机理是与过氧化作用有关。分析结构与活性关系 ,发现二苯基 丁二炔衍生物比二烷基取代丁二炔活性高 ,苯基上不同取代基也影响光活毒杀效果 ,它们的活性顺序是 :亚甲基二氧基 >甲氧基 >邻硝基 >间硝基>甲基酯
The photocatalytic activity of 11 synthetic polydienes on the 4th instar larvae of Culex quinque fasciatus was determined using a home-made photoactivation apparatus. It was found that some of the compounds exhibited markedly enhanced light activity under near UV light irradiation Activation of the poisoning effect, measured compound 5 (1 phenyl 4 (3,4 methylenedioxy) phenyl butadiyndyne) and non-photoprocessing LC50 were 0 35μg / mL and 8 89μg / mL. Experiments found that mosquitoes first contact with drugs, and then light treatment, can play a better toxic effect, and the poisoning effect and light time was positively correlated. Simulation field experiments show that the sun can significantly improve the efficacy of compound 5 poison mosquito larvae. The use of antioxidants for quenching experiments, indirect evidence that the photo-toxic compounds 5 killing mechanism is related to the role of peroxide. The relationship between structure and activity was analyzed. It was found that the activity of diphenylbutadienyne derivatives was higher than that of dialkyl substituted diacetylene, and the different substituents on phenyl groups also affected the phototoxicity. The order of their activity was: Oxy> methoxy> o-nitro> m-nitro> methyl ester