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为了判明胰岛素在Ⅰ型和Ⅱ型糖尿病及过度肥胖者经葡萄糖刺激后的释放表现,于1979年建立胰岛素放射免疫测定系统。观察了32例正常人,19例过度肥胖病人及16例Ⅰ型和154例Ⅱ型未接受过胰岛素治疗的糖尿病病人的释放情况。结果发现Ⅰ型糖尿病除反应低弱外,部分仍可有明显分泌峰和呈持续上升分泌;Ⅱ型糖尿病除典型分泌峰延迟外,尚见到反应迟钝,甚至低弱。肥胖病人空腹值升高,释放显著增加,高峰后移。此外,对Ⅰ型和Ⅱ型糖尿病间相互转化和痊愈的可能性进行了探讨。
In 1979, an insulin radioimmunoassay was established to determine the release of insulin following glucose-induced type I and II diabetes and over-obesity. 32 normal subjects, 19 obese patients and 16 type I and 154 type II non-insulin-treated diabetic patients were observed. The results showed that in addition to the type I diabetes response to the weak, some still have significant secretion peak and continued to rise; type Ⅱ diabetes in addition to the typical delay of peak secretion, still see the slow response, or even low. Obesity patients increased fasting, release increased significantly, the peak after the shift. In addition, the possibility of mutual transformation and recovery of type I and type II diabetes mellitus was explored.