Since serious fire occurred frequently in recent years, fire safety of high-rise building has attracted extensive attention. A National Basic Research Program (973 program) of China has been set up by Ministry of Science and Technology (MOST) of China in 2012 to meet the research requirements of fire safety in high-rise buildings. This paper reviews the current state of art of research on fire dynamics of high-rise buildings, including the up-to-date progress of this project. The following three subjects on fire dynamics of high-rise buildings are addressed in this review: the ejected flame and fire plume behavior over facade out of the compartment window, the flame spread behavior over facade thermal insulation materials, and the buoyancy-driven smoke transportation characteristics along long vertical channels in high-rise buildings. Prospective future works are discussed and summarized. A National Basic Research Program (973 program) of China has been set up by Ministry of Science and Technology (MOST) of China in 2012 to meet the research requirements of fire safety in high-rise buildings. This paper reviews the current state of art of research on fire dynamics of high-rise buildings, including the up-to-date progress of this project. The following three subjects on fire dynamics of high-rise buildings are addressed in this review: the ejected flame and fire plume behavior over facade out of the compartment window, the flame spread behavior over facade thermal insulation materials, and the buoyancy-driven smoke transportation characteristics along long vertical channels in high-rise buildings. Prospective future works are discussed and summarized.