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目的观察高剂量乙肝疫苗联合微卡对慢性HBV携带者的临床疗效。方法182例慢性HBV携带者随机分为对照组和治疗组。对照组予苦参素胶囊口服治疗,治疗组用高剂量乙肝疫苗联合微卡治疗,疗程均为3个月,观察患者肝功能、乙肝标志物、HBVDNA和外周血T淋巴细胞亚群的变化。结果综合疗效分析,治疗组总有效率28.1%,对照组总有效率16.3%;治疗组CD4+上升较对照组明显,e抗原血清转换率明显增加,与对照组比较,差异有统计学意义(P<0.05)。治疗组HBVDNA水平明显降低,但与对照组比较,差异无统计学意义(P>0.05)。结论高剂量乙肝疫苗联合微卡能提高慢性HBV携带者细胞免疫功能,提高e抗原血清转换率,降低HBVDNA水平,对慢性HBV携带者有一定疗效。
Objective To observe the clinical effect of high-dose hepatitis B vaccine combined with micro-card on chronic HBV carriers. Methods 182 cases of chronic HBV carriers were randomly divided into control group and treatment group. The control group was orally treated with matrine capsules. The treatment group was treated with high-dose hepatitis B vaccine combined with micro-card. The course of treatment was 3 months. The changes of liver function, hepatitis B markers, HBVDNA and T lymphocyte subsets in peripheral blood were observed. Results The total effective rate was 28.1% in the treatment group and 16.3% in the control group. The increase of CD4 + in the treatment group was more obvious than that in the control group, and the e antigen seroconversion rate was significantly increased. Compared with the control group, the difference was statistically significant (P <0.05). The treatment group HBVDNA levels were significantly lower, but compared with the control group, the difference was not statistically significant (P> 0.05). Conclusion High-dose hepatitis B vaccine combined with microcarrier can improve the cellular immune function of chronic HBV carriers, improve the e antigen seroconversion rate and reduce the level of HBVDNA, and have a certain curative effect on chronic HBV carriers.