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为了摸清静注万古霉素的使用趋势,对万古霉素的医生处方进行分类,确定万古霉素经验性应用的独立的预示因子,作者在一所具有900张病床的大学教学医院里以描述性流行病学研究、横断面研究和病例对照研究等方法对10年(1981年7月～1991年7月)中万古霉素的年度粗用量(g)和发生密度(g/1000病人日)及影响因素进行了研究。在随机选择的109例病人的医学记录中,作者把万古霉素的应用方式分类为预防性治疗、经验性治疗和特异性治疗,以分别评估其用量的相对频率。同时进行单变量和多变量分析,以确定万古霉素经验性治疗的决定因素。
In an effort to find out the trend toward intravenous vancomycin use, vancomycin’s physician prescription was categorized to determine the independent predictor of empirical vancomycin use in a 900-bed college teaching hospital to characterize (G) and density of occurrence (g / 1000 patient days) of vancomycin in 10 years (from July 1981 to July 1991) by means of epidemiological studies, cross-sectional studies and case- And influencing factors were studied. In the medical records of 109 randomly selected patients, the authors categorized vancomycin as prophylactic, empirical, and specific treatment to assess the relative frequency of their use, respectively. Univariate and multivariate analyzes were performed simultaneously to determine the determinants of empirical treatment of vancomycin.