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近年来,随着科技进步与人民生活水平的提高,肥胖的发生率极大增加,肥胖是2型糖尿病的易患因素,胰岛素抵抗(IR)是肥胖和2型糖尿病的共同病理基础。因此,对于IR的研究是治疗2型糖尿病的关键。脂肪组织是一个功能活跃的内分泌器官,具有重要的内分泌功能,产生并释放多种脂肪细胞因子,其中一些脂肪细胞因子可以通过腺苷酸激活蛋白激酶(AMPK)途径改善IR,另外一些通过其他的途径影响IR及相关疾病。研究脂肪细胞因子与AMPK对改善IR、治疗糖尿病提供了新的途径。
In recent years, with the advancement of science and technology and improvement of living standards, the incidence of obesity has greatly increased. Obesity is a predisposing factor for type 2 diabetes. Insulin resistance (IR) is the common pathological basis of obesity and type 2 diabetes. Therefore, the study of IR is the key to the treatment of type 2 diabetes. Adipose tissue is a functionally active endocrine organ that has important endocrine functions to produce and release a variety of adipocytokines, some of which may improve IR through the AMPK pathway and others through other Pathways affect the IR and related diseases. The study of adipocytokines and AMPK has provided a new way to improve IR and treat diabetes.