大多数口服药物主要从小肠吸收,少量从胃吸收,因此,胃排空是影响其吸收速度的重要一环。本文用扑热息痛吸收模型研究健康老年和青年的胃排空情况,以阐明胃排空是否受年龄的影响。方法先各选10名无胃、食道和其它疾病史的健康老年人和青年人,进行一组先导性研究。受试者试验前9小时禁食,24小时前停用任何药物和烟酒。建立静脉通道后,将扑热息痛20mg/kg剂量,以100ml饮用水送服并开始计时。在0、5、10、20、30、40、50、60、70、80、90、110、130、150和180分钟时分别取血样测定扑热息痛含量。之后,方案进行两项调整:一是静脉通道在服药前1小时建立,以最大程度减少迷走神经对胃排空的影响;二是送服的 Most oral drugs are mainly absorbed from the small intestine, a small amount of absorption from the stomach, therefore, gastric emptying is an important part of its speed of absorption. In this paper, paracetamol absorption model of healthy elderly and young people to study the situation of gastric emptying to clarify whether gastric emptying is affected by age. Methods A selection of 10 healthy seniors and young people without a history of stomach, esophagus and other diseases were selected for a pilot study. Subjects were fasted 9 hours prior to the trial and discontinued of any drugs and tobacco and alcohol 24 hours prior to the test. After the establishment of intravenous access, the paracetamol 20mg / kg dose to 100ml of drinking water delivery and start timing. Blood samples were taken at 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 110, 130, 150 and 180 minutes for the determination of paracetamol content. After the program two adjustments: First, intravenous access established 1 hour before taking drugs to minimize the vagus nerve on gastric emptying; the second is served