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目的：研究黄芪总黄酮（ｔｏｔａｌｆｌａｖｏｎｏｉｄｓｏｆａｓｔｒａｇａｌｕｓ，ＴＦＡ）对缺血再灌注损伤的防护作用。方法：应用家兔失血性休克／再灌注模型（ｓｈｏｃｋ／ｒｅｐｅｒｃｕｓｉｏｎ，Ｓ／Ｒ），观察损伤后血浆中一氧化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）代谢终产物亚硝酸盐（ＮＯ２）的变化及ＴＦＡ和磷脂酶Ａ２阻断剂氯喹（Ｃｈｌｑ）治疗对其的影响。结果：数据表明Ｓ／Ｒ后２４ｈ内血浆中ＮＯ２含量，与血ｐＨ值及二氧化碳总量（ＴＣＯ２）下降呈正相关；ＴＦＡ和Ｃｈｌｑ可在一定程度上阻断ＮＯ的减少，且对维持体内酸碱平衡有一定作用。结论：ＴＦＡ对缺血再灌注损伤具有防护作用。
Objective: To study the protective effect of total flavonoids (totalflavonoid sofastragalus) on ischemia-reperfusion injury. METHODS: The rabbit hemorrhagic shock/reperfusion model (shock/repercusion, S/R) was used to observe the change of nitric oxideend (NO) end-product nitrite (NO2) in plasma and TFA after injury. The effects of chloroquine (Chlq) treatment with the phospholipase A2 blocker. RESULTS: The data showed that plasma NO2 content was positively correlated with the decrease of plasma pH and total carbon dioxide (TCO2) within 24 hours after S/R; TFA and Chlq could block NO reduction to a certain extent and maintain the body’s acid and alkalinity. Balance has a role. Conclusion: TFA has a protective effect on ischemia-reperfusion injury.