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本文通过正常孕妇葡萄糖胰岛素释放试验,计算IGI,以及部分胰岛素拮抗激素,包括hGH(HPL)、T_3、T_4、~(125)I-T_3 MAA吸收比值测定,发现(1)妊娠期空腹血糖较非孕期低,尤以孕中期为甚;(2)妊娠早、中期有18％左右的亚临床低血糖症;(3)妊娠中胎盘分泌的拮抗激素特别是HPL(与hGH有交叉反应)增加胰岛负荷;(4)胰岛负荷增加表现为空腹高胰岛素血症,以及服糖后血糖升高,尤以孕后期为甚,IGI反应也增强,尤以孕中期为著。上述结果揭示妊娠有致糖尿病倾向,因此对超重或疑有糖尿病孕妇在妊娠期宜密切随访OGTT。
In this paper, normal pregnant women glucose insulin release test, calculated IGI, and some insulin antagonist hormones, including hGH (HPL), T_3, T_4, ~ (125) I-T_3 MAA absorption ratio was measured and found (1) gestational fasting blood glucose than non- Pregnancy is low, especially in the second trimester; (2) early pregnancy, mid-18% of subclinical hypoglycemia; (3) placental secretion of antagonist hormones, especially HPL (cross-reaction with hGH) increased islet Load; (4) increased islet load performance for fasting hyperinsulinemia, and elevated blood sugar after taking sugar, especially in late pregnancy, IGI response also increased, especially in the second trimester. The above results reveal that pregnancy has a tendency to cause diabetes, so overweight or suspected diabetes pregnant women should be closely followed during pregnancy OGTT.