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患者,女,46岁。入院诊断:(1)高血压缓进Ⅱ期,(2)冠心病。1995年11月1日入院,既往无药物过敏史。血压BP16/12kPa,P74～78次/min;临床生化:胆固醇4.9mmol/L,甘油三酯1.56mmol/L;超声心动图提示:(1)左房稍大,左室顺应性减低,左室轻度肥厚,(2)二尖瓣轻度返流;自述头晕,胸部不适。医嘱:硝酸异山梨醇酯(消心痛)10mg,tid;尼群地平10mg,bid口服。患者第一次服用消心痛后,自感胃部有不适,1日剂量服完后,病人晚上感觉大腿肌肉疼痛,渐加重至运动受阻,疼痛难忍,约持续1h左右,疼痛渐减轻。第2d上午又服10mg,症状又现,查房时患
Patient, female, 46 years old. Admission diagnosis: (1) hypertension into the phase Ⅱ, (2) coronary heart disease. November 1, 1995 admission, past history of drug allergy. Blood pressure BP16 / 12kPa, P74 ~ 78 times / min; Clinical biochemistry: cholesterol 4.9mmol / L, triglyceride 1.56mmol / L; Echocardiography: (1) left atrial slightly larger, reduced left ventricular compliance, left ventricular Mild hypertrophy, (2) mild mitral regurgitation; readme dizziness, chest discomfort. Doctor’s advice: isosorbide dinitrate (heartburn) 10mg, tid; nitrendipine 10mg, bid oral. After the patient took the first heartburn, the self-sensed stomach had discomfort. After the first day of taking the dose, the patient felt thigh muscle pain at night, gradually increasing to obstruction of movement. The pain was unbearable for about 1 hour and the pain gradually decreased. 2d morning and served 10mg, the symptoms are present, ward rounds suffering