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目的介绍皮肤药动学研究进展。方法检索国内外相关资料,总结皮肤药动学研究的主要技术及各自的优缺点,重点介绍胶条剥离技术在皮肤药动学研究中的应用。结果在众多皮肤药动学研究方法中,侵入性较小的胶条剥离技术和微量渗析技术备受人们关注,具有很好的前景,但目前仍旧有很多已被认识的问题难以克服。结论建立有效的局部皮肤取材方法是皮肤药动学研究得以顺利开展的关键。
Objective To introduce the research progress of skin pharmacokinetics. Methods Retrieve the relevant data at home and abroad, summarize the main techniques of skin pharmacokinetics and their respective advantages and disadvantages, and highlight the application of strip stripping technology in skin pharmacokinetics. Results Among the many skin pharmacokinetic studies, the less invasive strip stripping techniques and microdialysis techniques have received much attention and are promising. However, there are still many problems that have been recognized so far. Conclusion The establishment of an effective method of local skin sampling is the key to the smooth development of skin pharmacokinetics.