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磺胺异噁唑(Sulfisoxazole)化学名为5-(4-氨基苯磺酰胺)-3,4-二甲基异噁唑〔5-(4-sulfanilamide)-3,4-dimethylisoxazole〕或称Gantrisin,Gantrosan,Foxisol.简称SIZ。本品为高效抑菌药,作用同SD。对大肠杆菌、痢疾杆菌、葡萄球菌作用较强,在血、尿中浓度高,维持有效浓度时间较长。在中性或酸性尿中溶解度大,不易析出结晶。主要用于泌尿系统感染及菌痢、流行性脑炎。本品与磺胺增效剂TMP联合应用,能显著增强疗效。本品为Hoffman-La-Roche创制,于1944年发表。1946年Schnizer R.J.做了抑菌试验,它对革兰氏阳性菌及阴性菌都有抑制作用。美、英、日等国已分别于1965年、1968年、1961年将磺胺异噁唑收载入药典。在美、日等国磺胺异嗯唑已成为磺胺药物中产量大的品种之一。
Sulfisoxazole is chemically named 5- (4-sulfanilamide) -3,4-dimethylisoxazole, also known as Gantrisin, Gantrosan, Foxisol. This product is highly effective bacteriostatic drugs, the role of SD. Escherichia coli, Shigella, staphylococcus a stronger role in the blood, urine concentration, to maintain a valid concentration for a long time. In neutral or acidic urine solubility, difficult to precipitate crystallization. Mainly used for urinary tract infection and bacillary dysentery, epidemic encephalitis. This product and sulfonamide synergist TMP combined application, can significantly enhance the efficacy. This product was created by Hoffman-La-Roche, published in 1944. In 1946, Schnizer R.J. made bacteriostasis test, which has inhibitory effect on Gram-positive bacteria and negative bacteria. The United States, Britain, Japan and other countries have respectively in 1965, 1968, 1961 sulfasalazole contained in Pharmacopoeia. In the United States, Japan and other countries Sulfamethoxazole has become one of the large-yielding varieties of sulfa drugs.