以甲氧基聚乙二醇钠为大分子引发剂,采用氧阴离子引发聚合反应合成甲氧基聚乙二醇-b-聚氰基丙烯酸乙酯两亲性嵌段共聚物(mPEG-b-PECA).采用GPC,1H-NMR,FTIR等方法对mPEG-b-PECA进行表征,结果表明聚合反应可控,聚合物相对分子质量分布窄.采用纳米沉淀技术制备负载地塞米松(DXM)的mPEG-b-PECA纳米粒(NPs)并采用LPSA,1H-NMR和TEM对纳米粒进行表征.mPEG-b-PECANPs呈球形,粒径小于100nm.采用HPLC法测定载药量(DL)和包封率(EE),结果表明DXM可以被mPEG-b-PECANPs有效负载,这为DXM和其他疏水性药物提供了一种潜在的给药途径. The methoxypolyethylene glycol-b-polycyanoacrylate amphiphilic block copolymer (mPEG-b-1) was synthesized by the oxyanion polymerization with methoxypolyethylene glycol as the macroinitiator. PECA) .The mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR.The results showed that the polymerization reaction was controlled and the molecular weight distribution of the polymer was narrow.Dexamethasone (DXM) mPEG-b-PECA nanoparticles (NPs) were synthesized and characterized by LPSA, 1H-NMR and TEM.mPEG-b-PECANPs were spherical and their particle size was less than 100 nm.The drug loading (DL) The results showed that DXM could be effectively loaded by mPEG-b-PECANPs, which provided a potential route of administration for DXM and other hydrophobic drugs.